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Education

Post Doctoral from Columbia University (Chemical Engineering, 1992)
Ph.D. from Harvard-MIT (Medical Engineering/Medical Physics, 1991)
M.S. from Massachusetts Institute of Technology (Mechanical Engineering, 1987)
B.S. from Simon Bolivar University, Caracas-Venezuela, (Mechanical Engineering, 1984)

Research Interests

DePaola’s research investigates the role of physical mechanisms on cellular behavior emphasizing its importance in the understanding of human disease, the development of new therapies, and the engineering of functional tissues. A major emphasis of her research is on hemodynamic regulation of vascular cell function in early atherosclerosis, gap junctional intercellular communication, and biophysical regulation of mammalian cell function with applications to vascular, bone and neural tissue engineering.

Professional Affiliations & Memberships

• American Association for the Advancement of Science (AAAS)
• American Institute of Medical and Biological Engineering (AIMBE)
• American Society for Cell Biology (ASCB)
• American Society for Engineering Education (ASEE)
• American Society of Mechanical Engineers (ASME)
• Biomedical Engineering Society (BMES)
• Global Engineering Deans Council (GEDC) Executive Committee 2015-2016
• Chair of Global Engineering Deans Council (GEDC) - 2017-2019
• Society of Women Engineers (SWE)
• Tau Beta Pi and Sigma Xi

Awards

• 2012 IEEE Woman in Engineering Award
• 2009 Woman of Achievement Award, Holland & Knight LLP.
• Carol and Ed Kaplan Endowed Chair Professorship
• Fellow, American Institute for Medical and Biological Engineering (AIMBE). ). Citation: "For pioneering work investigating the role of altered hemodynamics in the regulation of endothelial cell functions relevant to atherosclerosis"
• Appointed Member 2007-2010, Strategic Initiatives Committee of the Harvard-MIT Health Science and Technology (HST) Advisory Council
• Faculty Member of the Institute for Medicine and Engineering, University of Pennsylvania (1998-2007).
• US Delegate to the 5th Japan-USA-Singapore-China Conference on Biomechanics. Sendai, Japan (1998).
• Frontiers Alumna, US National Academy of Engineering, Frontiers of Engineering (1997)
• NSF Faculty Early Career Development (CAREER) Award (1996)

Publications

Selected Publications

1. 
   Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 12: 1254-1257 (1992). N DePaola, M.A. Gimbrone Jr, P.F. Davies, and C.F. Dewey Jr.
     
    
2.  Annual Review of Physiology, Vol. 59: 527-549 (1997). P.F. Davies, K.A. Barbee, M.V. Volin, A. Robotewskyj, J. Chen, L. Joshep, M.L. Griem, M.N. Wernick, E. Jacobs, D.C. Polacek, N. DePaola, and A.I. Barakat.
     
    
3. 
   Proceedings of the National Academy of Sciences, Vol. 96(6): 3154-3159 (1999). N. DePaola, P.F. Davies, W.F. Pritchard, L Florez, N. Harbeck, and D.C. Polacek.
     
    
4. 
   Trends in Biotechbology, Vol. 17, Issue 9: 347-351 (1999). P.F. Davies, D.C. Polacek, J. Handen, B.P. Helmke, and N. DePaola.
     
    
5. 
   American Journal of Physiology - Heart and Circulatory Physiology, Vol. 278: H469-H476 (2000). J.E. Phelps, N. DePaola.
    
    
6. 
   Annals of the New York Academy of Sciences, Vol. 947: 7-17 (2001). P.F. Davies, C. Shi, N. DePaola, B. Helmke, and D.C. Polacek.
    
    
7. 
   Annals of Biomedical Engineering, Vol. 29, Issue 8: 648-656 (2001). N. DePaola, J.E. Phelps, L. Florez, C.R. Keese, F.L. Minnear, I. Giaever, and P. Vincent.
    
    
8. 
   American Journal of Respiratory Cell and Molecular Biology, Vol. 26(4) 453-464 (2002). K.G. Birukov, A.A. Birukova, S.M. Dudek, A.D. Verin, M.T. Crow, X. Zhan, N. DePaola, and J.G.N. Garcia.
    
    
9. 
   American Journal of Physiology - Heart and Circulatory Physiology, Vol. 285: H1720-H1729 (2003). V. Rizzo, C. Morton, N. DePaola, J.E. Schnitzer, and P.F. Davies.
    
    
10. 
    American Journal of Physiology - Heart and Circulatory Physiology, Vol. 288: H194-H204 (2005). M.P. Burns and N. DePaola.
     
     
11. 
    Experimental Cell Research, Volume 304, Issue 1: 40-49 (2005) Y. Shikata, A. Rios, K. Kawkitinarong, N. DePaola, J.G.N. Garcia, K.G. Birukov.
     
     
12.  
    American Journal of Physiology - Heart and Circulatory Physiology, Vol. 290: H2015-H2023 (2005) E.E. Ebong, S. Kim, and N. DePaola.
     

Most Recent Publications

1. 
   Tissue Engineering Part C; Methods, Vol. 17, Issue 5: 589-595 (2011). C.M. Zwolinski, K.S. Ellison, N. DePaola, and D.M. Thompson.
    
    
2. 
   Pflugers Archiv - European Journal of Physiology, Vol. 465: 1293-1302 (2013). E.E. Ebong and N. DePaola
    
    
3. Fluid Biomechanics and Circulation
   Invited Book Chapter, in Biomechanics (Eds. Manuel Doblare, Jose Merodio and Jose Ma Goicolea Ruigomez), in UNESCO Encyclopedia, (Epub on EOLSS online ahead of print, Eolss Publishers, Paris, France, ), (2014). N. DePaola and M. Burns
    
4. Neural progenitor cells exhibit differential behavior on extracellular matrix produced by dynamically-stimulated endothelial cells
   Stem Cells and Development, (in print). K.S. Ellison, C. Zwolinski, M.R. Newman, E. Kokavay, S. Goderie, S. Temple, N. DePaola, and D.M. Thompson.

Patents

• N. DePaola and A.G. Ostrogorsky, “Diamagnetic force field bioreactor, U.S Patent, U.S. Pat. No. 7,482,154 (2009).
• D. Polacek, A. Ostrogorsky and N. DePaola, “Automatic Cooling Device and Method for Humans.” U.S. Application Serial No. 11/675,719 (Pending).
• N. DePaola and D. Polacek, “Methods of Establishing Intercellular Communication in an Endothelial Cell Layer and Uses Thereof”, 2006. International No. PCT/US2004/032577.
• N. DePaola, “ECIS/Flow System Instruction Manual: Apparatus Operation and Experimental Procedures”, Technical Report (25 pages). US Copyright Office Registration Number TX-701-386, 2004.